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bioactive compounds  (TargetMol)


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    TargetMol bioactive compounds
    Bioactive Compounds, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound+library/Bioactive+Compounds+Library+Max/pm42826556-88-4-6
    Average 94 stars, based on 26 article reviews
    bioactive compounds - by Bioz Stars, 2026-10
    94/100 stars

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    other:

    Article Title: Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1.
    Article Snippet: A compound library containing 60 natural compounds and erianin was obtained from TargetMol (Boston, MA, USA).

    Article Title: SHP-1 agonist SC-43 limits methicillin-resistant Staphylococcus aureus infection through inhibition of heme biosynthesis
    Article Snippet: ASTs were performed using a phase 1–3 clinical compound library (Topscience, China) to identify the candidates capable of inhibiting SA 29213 .

    Article Title: S100A8/A9-TMEM24 axis drives podocyte injury by impairing autophagy: A novel theranostic target for early diabetic nephropathy.
    Article Snippet: A compound library comprising approximately 2,800 molecules was utilized from the Topscience database, including FDA-approved drugs and natural product derivatives.

    Article Title: CZC54252 overcomes Osimertinib resistance by targeting EGFR C797S mutations
    Article Snippet: Subsequently, a cell viability-based phenotype screening was conducted in a drug repurposing compound library provided by TargetMol using these cell models, aiming to discover compounds that can inhibit the activity of EGFR C797S triple mutations and overcome Osimertinib resistance.

    Article Title: Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
    Article Snippet: A high-throughput drug screen was performed using a compound library consisting of 619 compounds, including 59 SGC epigenetic compounds, 380 TargetMol epigenetic inhibitors and 180 FDA-approved oncology drugs.

    Article Title: SHP-1 agonist SC-43 limits methicillin-resistant Staphylococcus aureus infection through inhibition of heme biosynthesis.
    Article Snippet: ASTs were performed using a phase 1–3 clinical compound library (Topscience, China) to identify the candidates capable of inhibiting SA29213.

    Article Title: Targeting the virulence factor suilysin: a structure-guided discovery of chebulinic acid as a potent antivirulence agent.
    Article Snippet: Background: : The rapid rise of bacterial resistance has compromised conventional antibiotic efficacy, emphasizing the need for antivirulence-based anti-infective strategies.. Purpose: : Targeting the pore-forming toxin suilysin (SLY), this study aimed to establish a surface plasmon resonance (SPR) screening platform to identify candidates that bind to SLY and to evaluate their antivirulence

    Article Title: Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1
    Article Snippet: A compound library containing 60 natural compounds and erianin was obtained from TargetMol (Boston, MA, USA).



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    Image Search Results


    Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.

    Journal: Molecular Therapy Oncology

    Article Title: PARP7 inhibitors enhance the immunogenic effects of radiation in pancreatic cancer cells

    doi: 10.1016/j.omton.2026.201258

    Figure Lengend Snippet: Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.

    Article Snippet: Apoptosis, necroptosis, and ferroptosis were inhibited using Q-VD-Oph (10 μM; TargetMol Chemicals), necrostatin-1 (10 μM; TargetMol Chemicals) and liproxstatin-1 (5 μM; TargetMol Chemicals), respectively.

    Techniques: Inhibition, Irradiation, Gene Expression, Control, Analysis, RNA Sequencing